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Acetyl L Carnitine Plc


Boosts energy and mobilises fat. Supports memory and cognitive function.


Unique: contains the more effective PLC and arginate forms of Acetyl-L-Carnitine



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Product Indications

Acetyl-L-Carnitine (ALC) is a fatigue-fighting amino acid used by the mitochondria in cells to produce energy from fats. Studies show that ALC supports memory in age-related memory loss and cognitive function. Acetyl-L Carnitine-PLC™ contains two of the most effective forms of ALC, namely ALC-arginate and Propionyl-L-Carnitine (PLC).

Product Composition

Each capsule contains:

Acetyl-L-Carnitine arginate dihydrochloride 350mg
Propionyl-L-Carnitine hydrochloride 350mg

Inactive ingredients: Hypromellose (cellulose) vegetarian capsule shell (gelatin free), magnesium stearate (vegetarian flow agent) and silicon dioxide.

Suitable for vegetarians.

Storage Instructions
Store in a cool dry place below 25°C. Keep out of the reach of children.

Pharmacological Action

Acetyl-L-carnitine is the acetylated form of L-carnitine with improved bioavailability. The main function of acetyl-L-carnitine is the mediation of transport of long-chain fatty acids across the inner mitochondrial membrane. First, long-chain fatty acids form esters with CoA (acyl-CoA) in a reaction catalyzed by acyl-CoA synthetase (palmitoyl-CoA in the case of palmitate) in the cytoplasm. The next enzyme, carnitine palmitoyl transferase I performs transesterification by producing fatty acyl-L-carnitine esters (palmitoyl-L-carnitine) on the external surface of the inner mitochondrial membrane. This enzyme is involved in muscle physiological adaptation and results in a reduction in the oxidation of fatty acids and increased glucose utilization. Transport of the long-chain fatty acyl-L-carnitine esters across the inner mitochondrial membrane is mediated by acylcarnitine translocase, a special transport system in exchange for free L-carnitine of mitochondrial origin. On the matrix side of the inner mitochondrial membrane, carnitine palmitoyl transferase II catalyzes regeneration of long-chain acyl-CoA (palmitoyl CoA) and it is this form that subsequently undergoes β-oxidation to provide energy. In skeletal and cardiac muscle, the medium chain fatty acids with eight to 12 carbons also require carnitine for oxidation. Acetyl-L-carnitine is structurally related to acetylcholine. It also serves as a precursor to acetyl coenzyme A, and supplies acetyl groups to acetylcholine making it superior to L-carnitine in this aspect. It also seems to promote acetylcholine release and increases choline acetyltransferase activity. Propionyl-L-carnitine also increases pyruvate flux into the Krebs Cycle, stimulates pyruvate dehydrogenase activity, has free radical scavenging activity, improves homeostasis in the coagulation cascade. Propionyl-L-carnitine improves energy, metabolism, and myocardial contractility in experimental models.

Dosage Directions

Adults and children over 12 years of age: Take 1-2 capsules twice daily on an empty stomach, before 4pm.

Product Warnings

Avoid if you are allergic to any of the ingredients. Don’t exceed indicated dose, nor combine with other medication or pre-existing illness without medical advice.

Side Effects

Side effects may include nausea, vomiting, gastrointestinal upset and agitation.


There are no known contraindications.

Product Interactions

Use with caution if you are taking blood thinning medication (e.g. warfarin).

Pregnancy & Breastfeeding

Safety during pregnancy and breastfeeding has not been established.

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