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Naturally High™

A herbal medicinal product for the treatment of the symptoms of mild depressive episodes. It contains clinically tested and patented Saffr’Activ® saffron extract which boosts brain serotonin to improve mood and reduce restlessness. It also contains L-Theanine, an amino acid with calming effects and St. John’s wort that modulates the effects of serotonin, dopamine, and norepinephrine.


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Naturally High™ is a herbal medicinal product for the treatment of the symptoms of mild depressive episodes. It also improves mood and boosts brain serotonin.

Product Composition

Each capsule contains the following active ingredients:

Saffron extract (Saffr’Activ®) 15mg
St. John’s wort extract 300mg
L-Theanine 125mg
Vitamin B6 (pyridoxal-5-phosphate) 12.5mg

Inactive ingredients: Hypromellose (cellulose) vegetarian capsule shell and magnesium stearate.

Suitable for vegans and vegetarians.

Storage Instructions

Store in a cool dry place below 25°C. Keep out of reach of children.

Pharmacological Action

Crocin 1, a constituent of Saffron extract is believed to responsible for its antidepressant effects. The St. John’s wort constituent’s hyperforin and adhyperforin appear to modulate the effects of serotonin, dopamine, and norepinephrine, and may inhibit reuptake of these neurotransmitters. Theanine is speculated to produce calmative effects by increasing serotonin, dopamine, and gamma-aminobutyric acid (GABA) levels. Preliminary hypotheses suggest that because pyridoxine increases serotonin and GABA levels in the blood it may help with depression.

Dosage Directions

Take 1 capsule twice daily with food.

Beneficial effects are usually seen after 1 week of use.

Product Warnings

Do not exceed recommended dosages unless on the advice of a healthcare practitioner. Do not use this product if you are hypersensitive (allergic) to any of the ingredients. If you are on any medication or suffering from any medical condition, it is advisable to seek medical advice before starting any new medicine, supplement or remedy. This medicine has not been evaluated by the Medicines Control Council. This medicine is not intended to diagnose, treat, cure or prevent any disease.

Do not use continually for more than 18 weeks without consulting your healthcare practitioner. Avoid prolonged exposure to sunlight, ultraviolet light (UV) or UV therapy. Consult a healthcare practitioner if symptoms persist. Consult a healthcare practitioner if symptoms worsen.

Individuals should consult a healthcare practitioner prior to use if taking anti-anxiety medications, seizure medications, antihistamines, bronchodilators, muscle relaxants or opiates.

Side Effects

Side effects may include mild gastrointestinal disturbances, nausea, restlessness and headaches. Hypersensitivity, such as allergy, has been known to occur; in such case, discontinue use.


Do not use Naturally High™ if taking cancer medications, blood thinning medication (e.g. warfarin), antidepressant medications (e.g. selective serotonin reuptake inhibitors (SSRIs), HIV medication, cardiovascular medications, immunosuppressant medication, and/or contraceptive medications.


Naturally High™ induces the activity of CYP3A4, CYP2C9, CYP2C19 and P-glycoprotein. The concomitant use of cyclosporine, tacrolimus for systemic use, amprenavir, indinavir and other protease inhibitors, irinavir and warfarin is contraindicated. Special care should be taken in case of concomitant use of all medicinal substances of which the metabolism is influenced by CYP3A4,
CYP2CP, CYP2C19 or P-glycoprotein (e.g. amitriptyline, fexofenadrine, benzodiazepines, methodone, simvastatin, digoxin, finasteride), because a reduction of plasma concentrations is possible. The reduction of plasma concentrations of oral contraceptives may lead to increased intermenstrual bleeding and reduced safety in birth control. Prior to elective surgery possible interactions with products used during general and regional anaesthesia should be identified. If necessary Naturally High™ should be discontinued. The elevated enzyme activity returns within 1 week after cessation to normal levels. Naturally High™ may contribute to serotonergic effects when combined with antidepressants such as serotonin reuptake inhibitors (e.g. sertraline, paroxetine, nefazodone), buspirone or with triptans.
Individuals taking prescription medication should consult their healthcare practitioner before using Naturally High™.

Pregnancy and Breastfeeding

Not safe for use during pregnancy and whilst breastfeeding.

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