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Trimethylglycine

TMG

A nutrient which plays an important role in the health of the cardiovascular system. TMG works closely with other nutrients such as SAMe, natural folate, vitamin B6 and vitamin B12 to reduce homocysteine levels in the bloodstream. However, research is unclear whether homocysteine is a cause of cardiovascular disease, or if it is a marker (effect) of existing cardiovascular disease. Studies have shown that TMG may help protect against fatty deposits in the liver, which can occur from chronic alcohol use, protein malnutrition, obesity, poorly controlled diabetes, and other causes. TMG is a mood modifier and can therefore have a positive effect on mood by relaxing the mind. Vitamin B6, vitamin B12 and natural folate help effectively break down homocysteine.

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Product Indications

Trimethylglycine (TMG) is a nutrient which plays an important role in the health of the cardiovascular system. TMG works closely with other nutrients such as SAMe, folic acid, vitamin B6 and vitamin B12 reduce potentially toxic levels of homocysteine in the bloodstream. However, research is unclear whether homocysteine is a cause of cardiovascular disease. Studies have shown that TMG may help protect against fatty deposits in the liver, which can occur from chronic alcohol use, protein malnutrition, obesity, poorly controlled diabetes, and other causes. TMG is a mood modifier and can therefore have a positive effect on mood by relaxing the mind.

Product Composition

Each capsule contains the following as active ingredients:Trimethylglycine (betaine) 450mgVitamin B6 (pyridoxal-5-phosphate) 10mgVitamin B12 (methylcobalamin) 20µgFolic Acid (L-5-methyltetrahydrofolate calcium) 50µgSugar free.

Storage Instructions

Store in a cool dry place below 25°C, out of the reach of children.

Pharmacological Action

Trimethylglycine is naturally occurring in the body and is produced by oxidation of choline in the liver and kidneys. It is a methyl derivation of the amino acid choline. Trimethylglycine is an osmolyte, which maintains normal cell volume and protects intracellular cell volume under conditions of osmotic stress. By this mechanism it protects the kidneys from high levels of electrolytes and urea. Trimethylglycine can donate a methyl group to remethylate homocysteine into methionine. Methionine is the precursor to S-adenosylmethionine (SAMe), which is used as a methyl donor for many important pathways in the human body. SAMe is involved in the methylation of phosphatidylethanolamine to form phosphatidylcholine, which enhances secretion of very low density lipoprotein (VLDL) to transport fat out of the liver. Trimethylglycine can therefore act as a lipotrope, preventing or reducing accumulation of fat in the liver, such as occurs in non-alcoholic steatohepatitis and other forms of fatty liver disease. Due to trimethylglycine’s relationship with SAMe it may be useful as part of an oral therapy for depression. Vitamin B6, Vitamin B12 and folate have been added as they support the function of trimethylglycine. These nutrients work in two ways to metabolise homocysteine: by trans-sulfuration and remethylation. Folate and vitamin B12 are co-factors that are required for the remethylation of homocysteine back to methionine. Trans-sulfuration of homocysteine results in degradation of homocysteine to cystathionine and then to cysteine by Vitamin B6 dependent enzymes.

Dosage Directions

Adults and children over 12 years of age: Take 2-4 capsules twice daily or as recommended by your health care provider. Absorption is maximised when consumed on an empty stomach.

Product Warnings

Do not exceed recommended dosages unless on the advice of a health care provider. Do not use this product if you are allergic to any of the ingredients. If you are on any medication or suffering from any medical condition, it is advisable to seek medical advice before starting any new medicine, supplement or remedy.

Safety in children has not been established.

Side Effects

Side effects reported include nausea, gastrointestinal discomfort, diarrhoea and body odour. If muscle tension or headaches occurs reduce dosage.

Contraindications

There are no known contraindications.

Product Interactions

Renal disease: Based on clinical trials, individuals with renal disease may experience increases in total cholesterol, LDL, HDL and triglycerides when trimethylglycine is taken with folic acid and vitamin B6.

Pregnancy & Breastfeeding

Safety in pregnancy and breastfeeding has not been established, do not use.

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