Grapefruit contains flavonoids that can adversely react to prescription medicines.
The breakfast favourite that we all know as grapefruit was originally discovered in Barbados in 1750 by Griffith Hughes. He called it the “forbidden fruit” as he, at the time, was looking for the origin of the tree of good and evil in the Garden of Eden. It became known as grapefruit because it grows hanging in clusters, much like grapes[i].
BE AWARE OF INTERACTIONS
Grapefruit is packed with a host of healthy nutrients, including potassium, vitamin C, pectin, fibre and flavonoids that are very good for us[ii]. The flavonoids contained in grapefruit do, however, interact with many prescription medications that can lead to side effects or even reduce their effectiveness. For those of you who regularly enjoy your grapefruit with breakfast, it’s important to be aware of possible interactions with the following medications.
|Medication||Increase effectiveness and side effects of medication||Reduced effectiveness of the medication|
|Benzodiazepines (many sleeping tablets and tranquilisers fall into this category)||Yes||No|
|Calcium channel blockers for blood pressure (amlodipine, felodipine, nifedipine, nisoldipine, diltiazem)||Yes||No|
|Carvedilol (blood pressure)||Yes||No|
|Propanolol (blood pressure and heart rate)||Yes||No|
|Proton pump inhibitors (heartburn and ulcers)||Yes||No|
|SSRI antidepressants (citalopram, sertraline)||Yes||No|
|Sibutramine (appetite suppressant)||Yes||No|
|Dextromethorphan (cough suppressant)||Yes||No|
|Statins – cholesterol medicines (lovastatin, simvastatin, atorvastatin)||Yes||No|
|Quinidine (heart medication)||No||Yes|
|Sildenafil (erectile dysfunction)||Yes||No|