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Arginine 0

Arginine

An amino acid useful for angina, high blood pressure, congestive heart failure and heart health. L-arginine boosts nitric oxide levels, which causes blood vessel relaxation (vasodilation). L-arginine also triggers the body to make protein and has been studied for wound healing, bodybuilding, enhancement of sperm production and prevention of wasting in people with critical illnesses. L-arginine also stimulates the body to release growth hormone and may enhance sexual performance. Note: Studies indicate that people who have already had heart attacks should not use arginine as it may worsen their condition.

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Product Indications

L-Arginine is an amino acid useful for angina, high blood pressure, congestive heart failure and heart health. L-Arginine may assist in alleviating the pain and discomfort associated with cystitis. L-Arginine may facilitate muscle growth by inhibiting muscle loss as it is required for the transport of the nitrogen used in muscle metabolism. L-Arginine stimulates the release of human growth hormone (HGH) from the pituitary gland. It also assists with sexual performance in men.

Product Composition

Each capsule contains the following as active ingredients:

L-arginine hydrochloride 700mg

Inactive ingredients: Hypromellose (cellulose) vegetarian capsule shell (gelatine free), microcrystalline cellulose, magnesium stearate (vegetarian – flow agent), magnesium silicate, silicon dioxide and colloidal silicon dioxide.

Storage Instructions

Store in a cool dry place below 25°C. Keep out of the reach of children.

Pharmacological Action

L-Arginine is an amino acid necessary for protein synthesis. L-Arginine is a very important component of the vascular system. L-Arginine is a substrate for the nitric oxide synthase (NOS) enzyme. NOS in vascular endothelial cells converts L-arginine to nitric oxide (NO), also known as endothelial derived relaxation factor (EDRF), which causes vasodialation. L-arginine can improve coronary endothelial function and brachial artery endothelium-dependent dilation and reduces monocyte/ endothelial cell adhesion. The conversion of L-arginine to NO can reduce blood pressure. Individuals with diabetes appear to have low levels of L-arginine which could be a contributing factor in the development of peripheral vascular disease seen in diabetics. L-Arginine has other actions on the cardiovascular system independent of the conversion to NO. L-Arginine can directly reduce blood viscosity, reduce the activity of angiotensin converting enzyme, and reduce lipid peroxidation. L-Arginine is also metabolised to L-ornithine, then to L-proline, which is used in collagen synthesis and wound healing. Other physiologic actions include stimulating the release of growth hormone (GH), prolactin, glucagon, and insulin. L-Arginine also increases gastrin concentrations and inhibits tubular re-absorption of protein. L-Arginine has been shown to reduce urinary voiding discomfort, lower abdominal pain and vaginal/ urethral pain. L-Arginine also decreased urinary frequency during both the day and night.

Dosage Directions

Take 2-3 capsules twice daily, or as recommended by your medical practitioner. Take on an empty stomach.

Product Warnings

Do not exceed recommended dosages unless on the advice of a health care provider. Do not use this product if you are allergic to any of the ingredients. If you are on any medication or suffering from any medical condition, it is advisable to seek medical advice before starting any new medicine, supplement or remedy.

Safety in children has not been established.

Side Effects

Side effects may include gastrointestinal irritation, headache, diarrhoea, gout, allergic response, airway inflammation and exacerbation of asthma.

Contraindications

Myocardial Infarction: There is some concern that L-arginine might worsen the outcome in individuals following a myocardial infarction.

Pre-existing cancers: There is preliminary evidence that arginine supplementation could accelerate the growth of certain pre-existing cancerous conditions known as melanomas or hepatocellular carcinomas.

Product Interactions

Antihypertensive medicines: Concomitant use might cause additive anti-hypertensive effects, use with caution.

Nitrates: Concomitant use might cause additive anti-hypertensive effects, use with caution.

Sildenafil: Concominant use might result in additive vasodilation and cause hypotension, use with caution.

Special Precautions

Herpes Virus: L-Arginine could exacerbate this condition, as L-arginine may be necessary for viral replication.

Surgery: L-Arginine may affect blood pressure and should be discontinued at least 2-weeks before elective surgical procedures.

Pregnancy & Breastfeeding

Safety in pregnancy and breastfeeding has not been established.

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